SLC41A2 and CLN5

Data Source:
BioGRID (two hybrid)

		SLC41A2	CLN5
Description		solute carrier family 41 member 2	CLN5 intracellular trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Inorganic Cation Transmembrane Transporter Activity	Protein Binding Mannose Binding Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Metal Ion Transport Cation Transmembrane Transport	Signal Peptide Processing Lysosome Organization Lysosomal Lumen Acidification Brain Development Neurogenesis Protein Catabolic Process Retrograde Transport, Endosome To Golgi Neuron Maturation Glycosylation Positive Regulation Of GTP Binding
Pathways		Metal ion SLC transporters
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170)	Blood protein levels ( 30072576) Morning vs. evening chronotype ( 26835600) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		31 interacting genes: AQP6 CD79A CLN5 CREB3 EBP ERGIC3 ERVFRD-1 FATE1 FNDC9 FUT3 GJA5 GJB5 GPR151 GPR42 GPX8 IGFBP5 IL27RA KASH5 KIR3DL3 LDLRAD1 LEUTX LIME1 LMNA LY6G6C LYVE1 MFF PDCD1LG2 PVR SHISAL1 SSMEM1 TMEM237	8 interacting genes: FDFT1 GPR152 IGF2 INS-IGF2 PLPP6 SLC41A1 SLC41A2 TMEM31
Entrez ID		84102	1203
HPRD ID		15389	07619
Ensembl ID		ENSG00000136052	ENSG00000102805
Uniprot IDs		Q96JW4	A0A024R644 O75503
PDB IDs			6R99
Enriched GO Terms of Interacting Partners?
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