SPNS1 and ADORA2A

Data Source:
BioGRID (two hybrid)

		SPNS1	ADORA2A
Description		sphingolipid transporter 1 (putative)	adenosine A2a receptor
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Lysosomal Membrane Integral Component Of Membrane	Golgi Membrane Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Dendrite Axolemma Neuronal Cell Body Presynaptic Active Zone Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	G Protein-coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process	Lipid Transport Transmembrane Transport	G Protein-coupled Adenosine Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission, Cholinergic Central Nervous System Development Blood Coagulation Sensory Perception Locomotory Behavior Blood Circulation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Glutamate Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Norepinephrine Secretion Response To Caffeine Synaptic Transmission, Glutamatergic Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Locomotion Vasodilation Response To Drug Eating Behavior Negative Regulation Of Vascular Permeability Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Astrocyte Activation Neuron Projection Morphogenesis Positive Regulation Of Protein Secretion Regulation Of Mitochondrial Membrane Potential Membrane Depolarization Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Prepulse Inhibition Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Synaptic Vesicle Exocytosis
Pathways			NGF-independant TRKA activation Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production
Drugs			Caffeine Theophylline Mefloquine Lamotrigine Adenosine Dyphylline Pentoxifylline Enprofylline Oxtriphylline Theobromine Binodenoson Defibrotide Apadenoson Atl146e Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol Doxofylline Istradefylline 8-chlorotheophylline
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Educational attainment ( 25201988)	Acne (severe) ( 24927181) Coffee consumption (cups per day) ( 31217584) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		8 interacting genes: ADORA2A BCL2 BCL2L1 BDKRB2 CCR8 CCR9 CHRM5 HTR2C	22 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 ADA BET1 CHN1 CYTH2 DRD2 GPR37 HNRNPH3 HRH3 NAMPT NECAB2 PDHB POMZP3 PPM1J RHBDD2 SLC25A39 SLC4A1AP SPNS1 SYNGR1
Entrez ID		83985	135
HPRD ID		11599	00043
Ensembl ID		ENSG00000169682	ENSG00000128271
Uniprot IDs		A0A024QZ93 Q9H2V7	A8K1F6 B3KVQ4 P29274 X5DNB4
PDB IDs			1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY 4UG2 4UHR 5G53 5IU4 5IU7 5IU8 5IUA 5IUB 5JTB 5K2A 5K2B 5K2C 5K2D 5MZJ 5MZP 5N2R 5NLX 5NM2 5NM4 5OLG 5OLH 5OLO 5OLV 5OLZ 5OM1 5OM4 5UIG 5UVI 5VRA 5WF5 5WF6 6AQF 6GDG 6GT3 6JZH 6MH8 6PS7 6S0L 6S0Q 6ZDR 6ZDV
Enriched GO Terms of Interacting Partners?
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