KRTAP3-1 and GNE

Data Source:
BioGRID (two hybrid)

		KRTAP3-1	GNE
Description		keratin associated protein 3-1	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Cytoplasm Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	Keratinization	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Keratinization	Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS			Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		82 interacting genes: ADAM12 AGXT ANAPC11 BMP7 C20orf85 CDKN1A CELA2B CERK CFP CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PPP1R32 PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SMARCC1 SPAG8 TEKT3 TEX37 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446	65 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16
Entrez ID		83896	10020
HPRD ID		13937	04825
Ensembl ID		ENSG00000212901	ENSG00000159921
Uniprot IDs		Q9BYR8	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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