H2AC20 and RBBP4

Data Source:
HPRD (in vitro)

		H2AC20	RBBP4
Description		H2A clustered histone 20	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Nucleosome Nucleus Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol Sin3 Complex NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Chromatin Silencing Biological_process	DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Cell Cycle Negative Regulation Of Cell Population Proliferation Chromatin Assembly CENP-A Containing Nucleosome Assembly ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle Response To Growth Hormone Negative Regulation Of G0 To G1 Transition Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS
Drugs
Diseases
GWAS
Interacting Genes		74 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H2BC21 H3C1 H4C1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8	64 interacting genes: AEBP2 ANXA7 ARMC12 BCL11A BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DHX30 ERCC6 ESR1 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4-16 H4C14 HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA3 KPNA5 LIN37 LIN52 LIN9 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 MYBL2 NR2E3 PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SP1 SP3 SPEN STAT5B SUMO2 SUV39H1 TK1 TSSK3 XRCC6
Entrez ID		8338	5928
HPRD ID		09107	04232
Ensembl ID		ENSG00000184260	ENSG00000162521
Uniprot IDs		Q16777	Q09028
PDB IDs		6Y5E	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16 6NQ3 6ZRC
Enriched GO Terms of Interacting Partners?
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