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AXIN1 and TRIM42
Data Source:
BioGRID
(two hybrid)
AXIN1
TRIM42
Description
axin 1
tripartite motif containing 42
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Molecular Function
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
Protein Binding
Zinc Ion Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
1,4-Dithiothreitol
Diseases
Hepatocellular carcinoma
Caudal duplication anomaly
GWAS
Adult body size (
32376654
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Bipolar disorder (body mass index interaction) (
24322204
)
Refractive astigmatism (
25367360
)
Interacting Genes
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
USP7
UTP14A
ZBTB26
ZFYVE19
145 interacting genes:
ADAMTSL4
AQP1
ARMC7
ARNT2
ARRDC3
ATG9A
AXIN1
BACH2
BEX2
C1orf109
CARD9
CATSPER1
CBY2
CCDC120
CCDC24
CCDC33
CDCA7L
CEP70
CERK
CHCHD2
CHRD
CREB5
CYSRT1
EFEMP2
EFHC2
EMD
FAM124B
FAM90A1
FBLN1
FCHO1
FNDC3B
GLI1
GLRX3
GLYCTK
GNE
GOLGA2
GUCD1
HOXA1
HOXC8
HSD3B7
IGFN1
IHO1
IKZF3
IL16
IQUB
KCTD9
KLHL38
KPRP
KRT13
KRT15
KRT34
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-2
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-7
KRTAP9-3
L3MBTL2
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LNX1
LONRF1
LZTS2
MAGOHB
MAPKBP1
MEIS2
MEOX2
MFAP1
MGAT5B
MID2
MTUS2
MVP
NBPF19
NEK8
NOTCH2NLA
OTX1
PCSK5
PHLDA1
PLSCR1
PLSCR4
PNMA1
POU4F2
PRKAB2
PROP1
PSMA1
PSMD9
PTGER3
R3HDM2
RAMAC
RCOR3
RUNX1T1
SCNM1
SHFL
SLIT1
SMARCC1
SMCP
SPAG8
SSX2IP
STK16
TASOR2
TCAF1
TFAP2D
TLX3
TMEM150A
TRAF1
TRAF2
TRAPPC2B
TRIM23
TRIM27
TXNDC5
VGLL3
VPS37A
VWC2L
YIPF3
YWHAQ
YY1
ZBTB1
ZNF330
ZNF414
Entrez ID
8312
287015
HPRD ID
04819
15559
Ensembl ID
ENSG00000103126
ENSG00000155890
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
Q8IWZ5
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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