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TRIM42 and PSMA1
Data Source:
BioGRID
(two hybrid)
TRIM42
PSMA1
Description
tripartite motif containing 42
proteasome 20S subunit alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Polysome
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Lipopolysaccharide Binding
RNA Binding
Endopeptidase Activity
Protein Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Bipolar disorder (body mass index interaction) (
24322204
)
Refractive astigmatism (
25367360
)
Alzheimer's disease (cognitive decline) (
23535033
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
27841878
)
HDL cholesterol levels (
32203549
)
High chromosomal aberration frequency (total) (
31586183
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32203549
32154731
)
Vitamin D levels (
25208829
)
Interacting Genes
145 interacting genes:
ADAMTSL4
AQP1
ARMC7
ARNT2
ARRDC3
ATG9A
AXIN1
BACH2
BEX2
C1orf109
CARD9
CATSPER1
CBY2
CCDC120
CCDC24
CCDC33
CDCA7L
CEP70
CERK
CHCHD2
CHRD
CREB5
CYSRT1
EFEMP2
EFHC2
EMD
FAM124B
FAM90A1
FBLN1
FCHO1
FNDC3B
GLI1
GLRX3
GLYCTK
GNE
GOLGA2
GUCD1
HOXA1
HOXC8
HSD3B7
IGFN1
IHO1
IKZF3
IL16
IQUB
KCTD9
KLHL38
KPRP
KRT13
KRT15
KRT34
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-2
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-7
KRTAP9-3
L3MBTL2
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LNX1
LONRF1
LZTS2
MAGOHB
MAPKBP1
MEIS2
MEOX2
MFAP1
MGAT5B
MID2
MTUS2
MVP
NBPF19
NEK8
NOTCH2NLA
OTX1
PCSK5
PHLDA1
PLSCR1
PLSCR4
PNMA1
POU4F2
PRKAB2
PROP1
PSMA1
PSMD9
PTGER3
R3HDM2
RAMAC
RCOR3
RUNX1T1
SCNM1
SHFL
SLIT1
SMARCC1
SMCP
SPAG8
SSX2IP
STK16
TASOR2
TCAF1
TFAP2D
TLX3
TMEM150A
TRAF1
TRAF2
TRAPPC2B
TRIM23
TRIM27
TXNDC5
VGLL3
VPS37A
VWC2L
YIPF3
YWHAQ
YY1
ZBTB1
ZNF330
ZNF414
169 interacting genes:
ABCD3
ABI2
ABI3
ACTN1
ACTN2
AGR2
APIP
APP
BANF2
BLZF1
C11orf49
C22orf39
CABP5
CALCOCO2
CBS
CCDC102B
CCDC136
CCDC153
CCDC85B
CCNH
CDA
CDKN2D
CDR2
CEP70
CEP72
CFAP206
CHMP1A
CINP
COG4
COG6
COIL
CRX
DCTD
DCTPP1
DDIT4L
DEF6
DLEU1
DYDC1
DYNLT1
EHMT2
EIF4A3
EMSY
ERBB2
FNDC11
GNPTAB
GOLGA2
GOLGA6A
GPHN
GSDMD
GUCD1
HEXIM2
HOMER3
HOMEZ
HOOK2
HOXC11
HSD17B14
HSF2BP
IFT20
IKZF1
IKZF3
INO80E
IPO13
KAZN
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS3
KRT13
KRT15
KRT19
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP4-1
KRTAP5-9
KRTAP6-3
LDB1
LDOC1
LMO2
LONRF1
LZTFL1
LZTS1
LZTS2
MAD1L1
MAPK1
MAPRE1
MAPRE3
MCM6
MID2
MIEF1
MKNK2
MKRN3
MLH1
MRFAP1L1
MSANTD4
MT-CO2
MTUS2
NAB2
NBPF19
NECAB2
NME7
NMI
NOP53
NOTCH2NLA
PCBD1
PCYT2
PICK1
PLK1
PM20D2
PNMA1
PNMA2
PNMA5
POLR1C
POMP
PPCDC
PRDM14
PRIMPOL
PRKN
PRPH
PSMA2
PSMA3
PSMA4
PSMA7
PSMB1
PSMB10
PSMB2
PSMB5
RAD54B
RBCK1
REL
RFC2
RGS19
ROPN1
SAT1
SFMBT1
SH3BP4
SH3GLB1
SLF2
SPDEF
SSX2IP
TCF12
TCF4
TDO2
TEKT4
TNFAIP1
TNR
TRAF1
TRAF5
TRIM10
TRIM23
TRIM27
TRIM42
TRIM54
TSC22D4
UBXN11
VCP
VIM
VMAC
WTAP
YPEL5
ZFAND1
ZMYND19
Entrez ID
287015
5682
HPRD ID
15559
04170
Ensembl ID
ENSG00000155890
ENSG00000129084
Uniprot IDs
Q8IWZ5
B4E0X6
P25786
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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