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CAPN1 and ATG5
Data Source:
BioGRID
(enzymatic study)
CAPN1
ATG5
Description
calpain 1
autophagy related 5
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Cytoplasm
Autophagosome
Cytosol
Axoneme
Membrane
Phagocytic Vesicle Membrane
Phagophore Assembly Site Membrane
Atg12-Atg5-Atg16 Complex
Mitochondria-associated Endoplasmic Reticulum Membrane
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Protein Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Receptor Catabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Mammary Gland Involution
Cornification
Self Proteolysis
Regulation Of NMDA Receptor Activity
Autophagosome Assembly
Autophagy Of Mitochondrion
Blood Vessel Remodeling
Regulation Of Cytokine Production Involved In Immune Response
C-terminal Protein Lipidation
Autophagy
Apoptotic Process
Cellular Response To Nitrogen Starvation
Response To Fungus
Macroautophagy
Antigen Processing And Presentation Of Endogenous Antigen
Negative Regulation Of Protein Ubiquitination
Aggrephagy
Negative Stranded Viral RNA Replication
Vasodilation
Response To Drug
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Autophagy Of Nucleus
Negative Thymic T Cell Selection
Otolith Development
Negative Regulation Of Phagocytosis
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Cell Development
Heart Contraction
Negative Regulation Of Cell Death
Protein Lipidation Involved In Autophagosome Assembly
Positive Regulation Of Mucus Secretion
Cellular Response To Nitrosative Stress
Positive Regulation By Symbiont Of Host Autophagy
Regulation Of Cilium Assembly
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Histone H4-K16 Acetylation
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Macroautophagy
Macroautophagy
PINK1-PRKN Mediated Mitophagy
Receptor Mediated Mitophagy
Negative regulators of DDX58/IFIH1 signaling
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS
Urate levels (
31578528
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Glucose homeostasis traits (
25524916
)
Limited cutaneous systemic scleroderma (
24387989
)
Monobrow (
27182965
)
Multiple myeloma (
27363682
)
Rheumatoid arthritis (
30423114
24390342
)
Systemic lupus erythematosus (
27399966
23273568
26502338
28714469
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
24387989
31672989
)
Visceral fat (
30942860
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
54 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
28 interacting genes:
ATG10
ATG12
ATG16L1
ATG16L2
ATP23
CALCOCO2
CAPN1
CAPN2
CCDC12
CCHCR1
FADD
FMR1
GRIPAP1
HOOK2
INCA1
IRGM
KEAP1
KIAA1328
MAD1L1
MEOX2
OPTN
PSMB11
RAB33B
RACK1
TECPR1
TEKT4
VCP
WDFY3
Entrez ID
823
9474
HPRD ID
00253
16051
Ensembl ID
ENSG00000014216
ENSG00000057663
Uniprot IDs
B2RDI5
B4DWH5
P07384
A9UGY9
Q7Z3H3
Q9H1Y0
PDB IDs
1ZCM
2ARY
4GDK
4GDL
4NAW
4TQ0
4TQ1
5D7G
5NPV
5NPW
Enriched GO Terms of Interacting Partners
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