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CAPN1 and COL3A1
Data Source:
HPRD
(two hybrid)
CAPN1
COL3A1
Description
calpain 1
collagen type III alpha 1 chain
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Extracellular Region
Collagen Type III Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Protease Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Receptor Catabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Mammary Gland Involution
Cornification
Self Proteolysis
Regulation Of NMDA Receptor Activity
Skeletal System Development
Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Heart Development
Response To Radiation
Response To Mechanical Stimulus
Peptide Cross-linking
Cerebral Cortex Development
Platelet Activation
Extracellular Matrix Organization
Collagen Fibril Organization
Response To Cytokine
Positive Regulation Of Rho Protein Signal Transduction
Wound Healing
Skin Development
Regulation Of Immune Response
Negative Regulation Of Immune Response
Supramolecular Fiber Organization
Negative Regulation Of Neuron Migration
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Collagenase clostridium histolyticum
Diseases
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Urate levels (
31578528
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Carotid intima media thickness x smoking interaction (
32117412
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Parkinson disease and lewy body pathology (
25663231
)
Platelet distribution width (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
54 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
14 interacting genes:
AP2B1
CAPN1
DDR1
DDR2
FGF7
HTRA1
MAG
MYOC
PCOLCE
PDGFA
PDGFB
SPARC
THBS1
VWF
Entrez ID
823
1281
HPRD ID
00253
00365
Ensembl ID
ENSG00000014216
ENSG00000168542
Uniprot IDs
B2RDI5
B4DWH5
P07384
P02461
PDB IDs
1ZCM
2ARY
2V53
3DMW
4AE2
4AEJ
4AK3
4GYX
6FZV
6FZW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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