TSSK3 and CENPN

Data Source:
BioGRID (two hybrid)

		TSSK3	CENPN
Description		testis specific serine kinase 3	centromere protein N
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Condensed Chromosome Kinetochore Nucleoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Multicellular Organism Development Spermatogenesis Cell Differentiation Intracellular Signal Transduction	Chromosome Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		67 interacting genes: ADAMTSL4 ARID5A ATP23 C15orf48 C2CD6 C9orf24 CCDC130 CENPN DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YPEL3 ZBTB25 ZMYND12	4 interacting genes: ALKBH7 CCDC103 OSGIN1 TSSK3
Entrez ID		81629	55839
HPRD ID		09635	12528
Ensembl ID		ENSG00000162526	ENSG00000166451
Uniprot IDs		Q96PN8	Q96H22
PDB IDs			6BUZ 6C0W 6EQT 6MUO 6MUP
Enriched GO Terms of Interacting Partners?
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