TSSK3 and TRIM35

Data Source:
BioGRID (two hybrid)

		TSSK3	TRIM35
Description		testis specific serine kinase 3	tripartite motif containing 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Molecular_function Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Multicellular Organism Development Spermatogenesis Cell Differentiation Intracellular Signal Transduction	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)
Interacting Genes		67 interacting genes: ADAMTSL4 ARID5A ATP23 C15orf48 C2CD6 C9orf24 CCDC130 CENPN DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YPEL3 ZBTB25 ZMYND12	49 interacting genes: ADIPOQ BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410
Entrez ID		81629	23087
HPRD ID		09635	15553
Ensembl ID		ENSG00000162526	ENSG00000104228
Uniprot IDs		Q96PN8	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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