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CAMK2B and TNPO2
Data Source:
BioGRID
(two hybrid)
CAMK2B
TNPO2
Description
calcium/calmodulin dependent protein kinase II beta
transportin 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Endocytic Vesicle Membrane
Sarcoplasmic Reticulum Membrane
Neuron Projection
Synapse
Nucleus
Cytoplasm
Molecular Function
Actin Binding
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
Biological Process
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Adaptation
Protein Autophosphorylation
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Synapse Structural Plasticity
Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Regulation Of Dendritic Spine Development
Positive Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Synapse Maturation
Regulation Of Cellular Response To Heat
Regulation Of Neuron Migration
Protein Import Into Nucleus
Pathways
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Fostamatinib
Diseases
GWAS
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Intracranial aneurysm (
29531279
)
Metabolic syndrome (
22399527
)
Osteoarthritis (hip) (
23989986
)
Systolic blood pressure (
30578418
)
Triglyceride levels (
32203549
)
Diffuse large B-cell lymphoma or multiple sclerosis (
31407831
)
Interacting Genes
56 interacting genes:
ACOT7
ACTN4
AP5B1
ARSA
ATXN1
CAMK2A
CAMK2D
CAMK2G
CAMK2N2
CCM2L
CDC37
COL4A3
DUS1L
ETS1
FAM171A2
GAPDH
GRIN2A
GRIN2B
ITPKA
KRT86
KRTAP1-1
KRTAP10-11
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
MAD2L2
MED18
MEOX2
MGAT5B
MORF4L1
MORF4L2
MRPL11
MVP
PHKB
PLCB3
PNKP
POLR3C
POP5
RAP2B
RBFOX2
RBPMS
RNF4
RPL11
RXRG
SEMA4G
SMYD3
SPRYD7
THRB
TNPO2
TNPO3
TTC5
YWHAB
ZBTB32
ZMYM5
52 interacting genes:
A1CF
APIP
BEND7
BIRC7
BIRC8
BLMH
C12orf40
C1orf94
CAMK2B
CAMK2D
CAMK2G
CCDC158
CRYAB
CTAG1A
CTAG1B
ELAVL1
EXOC5
FH
FTO
FUCA2
GCH1
GSC2
KLHL2
KLHL20
KLHL3
KRT75
KRTAP8-1
NME1
NUP98
NXF1
OTX2
PACSIN3
PDLIM7
PIK3CD
PINX1
PNMA5
POU6F2
PRMT8
PYCR1
RAN
RBM45
RPL4
RPRD1B
SERTAD3
SF1
TBX2
TCL1B
TERF1
THAP6
TRIM8
ZBTB32
ZC2HC1C
Entrez ID
816
30000
HPRD ID
12127
04301
Ensembl ID
ENSG00000058404
ENSG00000105576
Uniprot IDs
A4D2J9
B7Z1Z6
Q13554
A0A024R7F7
O14787
Q05D48
Q4LE60
PDB IDs
3BHH
Enriched GO Terms of Interacting Partners
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