TNPO2 and KLHL3

Data Source:
BioGRID (two hybrid)

		TNPO2	KLHL3
Description		transportin 2	kelch like family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding
	Biological Process	Protein Import Into Nucleus	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)	Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		52 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C	18 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 KLHL2 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 TNPO2 WNK1 WNK3 WNK4
Entrez ID		30000	26249
HPRD ID		04301	09011
Ensembl ID		ENSG00000105576	ENSG00000146021
Uniprot IDs		A0A024R7F7 O14787 Q05D48 Q4LE60	Q9UH77
PDB IDs			4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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