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PREX2 and CDC42
Data Source:
BioGRID
(fluorescent resonance energy transfer)
PREX2
CDC42
Description
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
cell division cycle 42
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Golgi Membrane
Storage Vacuole
Cytoplasm
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Golgi Transport Complex
Secretory Granule
Filopodium
Midbody
Leading Edge Membrane
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Apical Part Of Cell
Phagocytic Vesicle
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Schaffer Collateral - CA1 Synapse
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Thioesterase Binding
GBD Domain Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
G Protein-coupled Receptor Signaling Pathway
Adult Locomotory Behavior
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of GTPase Activity
Dendrite Morphogenesis
Sprouting Angiogenesis
Cardiac Conduction System Development
Endocytosis
Phagocytosis, Engulfment
Actin Filament Organization
Golgi Organization
Regulation Of Mitotic Nuclear Division
Nuclear Migration
Establishment Or Maintenance Of Cell Polarity
Integrin-mediated Signaling Pathway
Blood Coagulation
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Cell Migration
Protein Ubiquitination
Substantia Nigra Development
Cell Projection Assembly
Actin Cytoskeleton Organization
Macrophage Differentiation
Positive Regulation Of Cell Growth
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokinesis
Cdc42 Protein Signal Transduction
Cell Junction Assembly
Adherens Junction Organization
Cellular Protein Localization
Interleukin-12-mediated Signaling Pathway
Dendritic Cell Migration
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Viral RNA Genome Replication
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Establishment Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of DNA Replication
Positive Regulation Of JNK Cascade
Filopodium Assembly
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Pinocytosis
Neuron Fate Determination
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Filopodium Assembly
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Establishment Of Golgi Localization
Positive Regulation Of Synapse Structural Plasticity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Heart Contraction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Submandibular Salivary Gland Formation
Dendritic Spine Morphogenesis
Cellular Response To Interferon-gamma
Organelle Transport Along Microtubule
Actin Filament Branching
Positive Regulation Of Intracellular Protein Transport
Regulation Of Modification Of Postsynaptic Structure
Modification Of Synaptic Structure
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Regulation of PTEN stability and activity
GPVI-mediated activation cascade
EGFR downregulation
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
G beta:gamma signalling through CDC42
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Drugs
Aminophosphonic acid-guanylate ester
Guanosine-5'-Diphosphate
Diseases
GWAS
Systolic blood pressure (
30224653
)
Colorectal cancer (
25990418
)
Daytime sleep phenotypes (
27126917
)
Extremely high intelligence (
29520040
)
Gestational age at birth (maternal effect) (
28877031
)
Gynecologic disease (
31488892
)
Gynecologic disease (multivariate analysis) (
31488892
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Metabolite levels (
23823483
)
Uterine fibroids (
31488892
31249589
30194396
31649266
)
Uterine fibroids (MTAG) (
31488892
)
Interacting Genes
4 interacting genes:
CDC42
RAC1
RHOA
TGFBR1
382 interacting genes:
A2M
AARS1
ACADM
ACO1
ACO2
ACOT7
ACTR3
ADRM1
AGAP1
AGAP2
AHSG
AKR1B1
ALDH18A1
ANAPC13
ANXA11
ANXA2
AP3D1
APEX1
APOH
ARAP1
ARAP2
ARG1
ARHGAP1
ARHGAP10
ARHGAP11B
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP26
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP35
ARHGAP39
ARHGAP40
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF11
ARHGEF15
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF6
ARHGEF7
ARHGEF9
ARRB1
ARRB2
ATP5F1C
ATP5IF1
ATP5MF
ATP5PD
ATP6V1A
BAIAP2
BCAP31
BCCIP
BCR
BIRC2
BLMH
BNIP2
BTF3
BZW2
CALML5
CAPNS1
CAPZB
CARHSP1
CASP14
CASP3
CASP7
CBLL1
CBX3
CCN1
CDC42BPA
CDC42BPB
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
CDC42EP5
CDC42SE1
CDC5L
CDH1
CDKN2A
CFHR4
CGN
CMPK1
CNBP
CNOT1
COL1A1
COMT
COPA
COPE
COPG1
CPN1
CRIP2
CSE1L
CSN2
CSPG4
CTNNA1
DEF6
DEK
DHFR
DIAPH1
DIAPH2
DIAPH3
DNMBP
DOCK7
DOCK8
DOCK9
DPYSL2
DSG1
DSP
ECHS1
EDC4
EDF1
EEF1E1
EEF1G
EHD2
EHD4
EIF2AK2
EIF3D
EIF3F
EIF5
EIF5B
EPHA2
EPRS1
ERCC3
ERG28
ERICH6
ERRFI1
ETFA
FAM13B
FGD1
FGD2
FGD3
FGD4
FKBP10
FKBP1A
FKBP3
FLNA
FLNC
FMN2
FMNL2
FNBP1
FNBP1L
FTH1
G6PD
GALNT2
GART
GDI1
GIT1
GIT2
GLS
GMIP
GNB1
GRB2
GRWD1
GSR
GSTM5
H1-10
H1-5
H2BC13
HADH
HADHB
HDAC7
HDLBP
HERC2
HLA-G
HMGN1
HNRNPAB
HNRNPUL2
HSD17B10
HYOU1
IARS1
IGF2BP1
IPO5
IQGAP1
IQGAP2
ITSN1
JPT2
KARS1
KAT5
KHDRBS1
KIAA2026
KPNA2
KTN1
KYNU
LARS1
LCK
LGALS1
LGALS7
LONP1
LRIF1
LRP2
LYZ
MAP2K3
MAP3K10
MAP3K11
MAP3K19
MAP3K4
MAP4
MAPRE1
MARCKSL1
MARK4
MASTL
MATR3
MCF2L
MCM3AP
MCM6
MCM7
MDH1
MDK
METAP2
MRM1
MRPL49
MSH2
MT-CO1
MTDH
MUC12
MYO1C
MYO6
MYO9A
NAA15
NASP
NCAPD2
NCF2
NEK6
NIBAN2
NOP2
NPLOC4
NQO1
NUDT21
NUP155
OCRL
OLA1
OPHN1
P3H1
PABPC4
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PALLD
PARD3
PARD6A
PARD6B
PARD6G
PAXX
PCM1
PCNP
PDCD5
PDE6C
PDE6D
PGD
PGGT1B
PHAX
PHB2
PHPT1
PICALM
PIK3R1
PLD1
PLEKHG1
PLEKHG2
PLEKHG3
PLEKHG4
PLEKHG4B
PMS1
PPP2R1A
PRDX3
PREX2
PRKCA
PRKCG
PRKCI
PRKCZ
PSAT1
PSIP1
PSMB1
PSMC5
PSMC6
PSMD11
PSMD12
PSMD3
PSME3
PXDN
RAC2
RAP1GDS1
RARS1
RASGRF2
RBM39
RBM8A
RHOJ
RIOK3
RO60
RPL22
RPL23
RPS15
RPS21
RPS6KB1
RRM1
S100A9
SDHA
SEPTIN2
SERPINB1
SERPINB2
SERPINB3
SF1
SF3A2
SH3BGRL3
SH3D19
SLC16A3
SMC2
SNRNP70
SPATA13
SRGAP1
SRM
SRP72
SRSF1
SSB
SSX2IP
ST13
STARD8
STAT1
STAU1
STMN2
SYNE1
TBC1D3F
TBCA
TCEAL3
TIAM1
TMED10
TMED9
TMOD3
TMX1
TNFRSF10B
TNK2
TOR1AIP1
TP53
TPD52L2
TPM1
TRAF2
TRAF7
TRIM28
TRIM45
TRIM60
TRIO
TRIP10
TRRAP
TSFM
TTC12
TUBB3
TXNL1
TYMS
U2AF2
UBC
UBE2L3
UBR1
UGDH
UNC119
USP6
VARS1
VASP
VAV1
VRK2
WAS
WASF1
WASF2
WASL
WIPF1
XIAP
XPO1
YARS1
YWHAH
ZNF175
ZNF234
ZNF415
ZNF420
ZNF622
Entrez ID
80243
998
HPRD ID
13135
00309
Ensembl ID
ENSG00000046889
ENSG00000070831
Uniprot IDs
Q70Z35
A0A024RAA5
A0A024RAE6
P60953
PDB IDs
6BNM
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2KB0
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG
3QBV
3VHL
4DID
4ITR
4JS0
4YC7
4YDH
5CJP
5FI1
5HZK
5UPK
5UPL
6AJ4
6AJL
6SIU
6SUP
6TKY
6TKZ
Enriched GO Terms of Interacting Partners
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