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CDC42 and FLNA
Data Source:
HPRD
(in vitro)
CDC42
FLNA
Description
cell division cycle 42
filamin A
Image
GO Annotations
Cellular Component
Golgi Membrane
Storage Vacuole
Cytoplasm
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Golgi Transport Complex
Secretory Granule
Filopodium
Midbody
Leading Edge Membrane
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Apical Part Of Cell
Phagocytic Vesicle
Spindle Midzone
Extracellular Exosome
Mitotic Spindle
Schaffer Collateral - CA1 Synapse
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Thioesterase Binding
GBD Domain Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Biological Process
Sprouting Angiogenesis
Cardiac Conduction System Development
Endocytosis
Phagocytosis, Engulfment
Actin Filament Organization
Golgi Organization
Regulation Of Mitotic Nuclear Division
Nuclear Migration
Establishment Or Maintenance Of Cell Polarity
Integrin-mediated Signaling Pathway
Blood Coagulation
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Cell Migration
Protein Ubiquitination
Substantia Nigra Development
Cell Projection Assembly
Actin Cytoskeleton Organization
Macrophage Differentiation
Positive Regulation Of Cell Growth
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokinesis
Cdc42 Protein Signal Transduction
Cell Junction Assembly
Adherens Junction Organization
Cellular Protein Localization
Interleukin-12-mediated Signaling Pathway
Dendritic Cell Migration
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Viral RNA Genome Replication
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Establishment Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of DNA Replication
Positive Regulation Of JNK Cascade
Filopodium Assembly
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Pinocytosis
Neuron Fate Determination
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Filopodium Assembly
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Establishment Of Golgi Localization
Positive Regulation Of Synapse Structural Plasticity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Heart Contraction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Submandibular Salivary Gland Formation
Dendritic Spine Morphogenesis
Cellular Response To Interferon-gamma
Organelle Transport Along Microtubule
Actin Filament Branching
Positive Regulation Of Intracellular Protein Transport
Regulation Of Modification Of Postsynaptic Structure
Modification Of Synaptic Structure
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Actin Cytoskeleton Reorganization
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
GPVI-mediated activation cascade
EGFR downregulation
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
G beta:gamma signalling through CDC42
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Aminophosphonic acid-guanylate ester
Guanosine-5'-Diphosphate
Artenimol
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Colorectal cancer (
25990418
)
Daytime sleep phenotypes (
27126917
)
Extremely high intelligence (
29520040
)
Gestational age at birth (maternal effect) (
28877031
)
Gynecologic disease (
31488892
)
Gynecologic disease (multivariate analysis) (
31488892
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Metabolite levels (
23823483
)
Uterine fibroids (
31488892
31249589
30194396
31649266
)
Uterine fibroids (MTAG) (
31488892
)
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
382 interacting genes:
A2M
AARS1
ACADM
ACO1
ACO2
ACOT7
ACTR3
ADRM1
AGAP1
AGAP2
AHSG
AKR1B1
ALDH18A1
ANAPC13
ANXA11
ANXA2
AP3D1
APEX1
APOH
ARAP1
ARAP2
ARG1
ARHGAP1
ARHGAP10
ARHGAP11B
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP26
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP35
ARHGAP39
ARHGAP40
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF11
ARHGEF15
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF6
ARHGEF7
ARHGEF9
ARRB1
ARRB2
ATP5F1C
ATP5IF1
ATP5MF
ATP5PD
ATP6V1A
BAIAP2
BCAP31
BCCIP
BCR
BIRC2
BLMH
BNIP2
BTF3
BZW2
CALML5
CAPNS1
CAPZB
CARHSP1
CASP14
CASP3
CASP7
CBLL1
CBX3
CCN1
CDC42BPA
CDC42BPB
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
CDC42EP5
CDC42SE1
CDC5L
CDH1
CDKN2A
CFHR4
CGN
CMPK1
CNBP
CNOT1
COL1A1
COMT
COPA
COPE
COPG1
CPN1
CRIP2
CSE1L
CSN2
CSPG4
CTNNA1
DEF6
DEK
DHFR
DIAPH1
DIAPH2
DIAPH3
DNMBP
DOCK7
DOCK8
DOCK9
DPYSL2
DSG1
DSP
ECHS1
EDC4
EDF1
EEF1E1
EEF1G
EHD2
EHD4
EIF2AK2
EIF3D
EIF3F
EIF5
EIF5B
EPHA2
EPRS1
ERCC3
ERG28
ERICH6
ERRFI1
ETFA
FAM13B
FGD1
FGD2
FGD3
FGD4
FKBP10
FKBP1A
FKBP3
FLNA
FLNC
FMN2
FMNL2
FNBP1
FNBP1L
FTH1
G6PD
GALNT2
GART
GDI1
GIT1
GIT2
GLS
GMIP
GNB1
GRB2
GRWD1
GSR
GSTM5
H1-10
H1-5
H2BC13
HADH
HADHB
HDAC7
HDLBP
HERC2
HLA-G
HMGN1
HNRNPAB
HNRNPUL2
HSD17B10
HYOU1
IARS1
IGF2BP1
IPO5
IQGAP1
IQGAP2
ITSN1
JPT2
KARS1
KAT5
KHDRBS1
KIAA2026
KPNA2
KTN1
KYNU
LARS1
LCK
LGALS1
LGALS7
LONP1
LRIF1
LRP2
LYZ
MAP2K3
MAP3K10
MAP3K11
MAP3K19
MAP3K4
MAP4
MAPRE1
MARCKSL1
MARK4
MASTL
MATR3
MCF2L
MCM3AP
MCM6
MCM7
MDH1
MDK
METAP2
MRM1
MRPL49
MSH2
MT-CO1
MTDH
MUC12
MYO1C
MYO6
MYO9A
NAA15
NASP
NCAPD2
NCF2
NEK6
NIBAN2
NOP2
NPLOC4
NQO1
NUDT21
NUP155
OCRL
OLA1
OPHN1
P3H1
PABPC4
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PALLD
PARD3
PARD6A
PARD6B
PARD6G
PAXX
PCM1
PCNP
PDCD5
PDE6C
PDE6D
PGD
PGGT1B
PHAX
PHB2
PHPT1
PICALM
PIK3R1
PLD1
PLEKHG1
PLEKHG2
PLEKHG3
PLEKHG4
PLEKHG4B
PMS1
PPP2R1A
PRDX3
PREX2
PRKCA
PRKCG
PRKCI
PRKCZ
PSAT1
PSIP1
PSMB1
PSMC5
PSMC6
PSMD11
PSMD12
PSMD3
PSME3
PXDN
RAC2
RAP1GDS1
RARS1
RASGRF2
RBM39
RBM8A
RHOJ
RIOK3
RO60
RPL22
RPL23
RPS15
RPS21
RPS6KB1
RRM1
S100A9
SDHA
SEPTIN2
SERPINB1
SERPINB2
SERPINB3
SF1
SF3A2
SH3BGRL3
SH3D19
SLC16A3
SMC2
SNRNP70
SPATA13
SRGAP1
SRM
SRP72
SRSF1
SSB
SSX2IP
ST13
STARD8
STAT1
STAU1
STMN2
SYNE1
TBC1D3F
TBCA
TCEAL3
TIAM1
TMED10
TMED9
TMOD3
TMX1
TNFRSF10B
TNK2
TOR1AIP1
TP53
TPD52L2
TPM1
TRAF2
TRAF7
TRIM28
TRIM45
TRIM60
TRIO
TRIP10
TRRAP
TSFM
TTC12
TUBB3
TXNL1
TYMS
U2AF2
UBC
UBE2L3
UBR1
UGDH
UNC119
USP6
VARS1
VASP
VAV1
VRK2
WAS
WASF1
WASF2
WASL
WIPF1
XIAP
XPO1
YARS1
YWHAH
ZNF175
ZNF234
ZNF415
ZNF420
ZNF622
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
Entrez ID
998
2316
HPRD ID
00309
02060
Ensembl ID
ENSG00000070831
ENSG00000196924
Uniprot IDs
A0A024RAA5
A0A024RAE6
P60953
P21333
Q60FE5
Q6NXF2
PDB IDs
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2KB0
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG
3QBV
3VHL
4DID
4ITR
4JS0
4YC7
4YDH
5CJP
5FI1
5HZK
5UPK
5UPL
6AJ4
6AJL
6SIU
6SUP
6TKY
6TKZ
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
Enriched GO Terms of Interacting Partners
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