ANKRD55 and BOLA2

Data Source:
BioGRID (two hybrid)

		ANKRD55	BOLA2
Description		ankyrin repeat domain 55	bolA family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Iron-sulfur Cluster Binding
	Biological Process		Cellular Iron Ion Homeostasis Interleukin-12-mediated Signaling Pathway [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer
Pathways			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA levels ( 28628107) IgG glycosylation ( 23382691) Immature fraction of reticulocytes ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FEV1) ( 30061609) Macular thickness ( 30535121) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 27386562) Optic disc size ( 31809533) Pediatric autoimmune diseases ( 26301688) Post-traumatic stress disorder ( 27167565) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-negative) ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sero-negative rheumatoid arthritis ( 28706201) Triglycerides ( 20686565) Type 2 diabetes ( 27189021 22885922 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Urate levels ( 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		22 interacting genes: ABI2 ANKS1A BACH2 BANP BOLA2 BOLA2B CABP5 CFAP206 CLIC3 FHL2 FHL5 FRS3 HGS HSF2BP NCK2 NOXA1 PFDN5 PTK6 TEKT4 TRIM23 ZMYND19 ZSCAN1	32 interacting genes: ADAMTSL4 ANKRD55 BIRC2 BIRC7 C10orf55 C1orf94 CCDC138 CGGBP1 GLRX3 HDX ID3 IHO1 IL16 MBD3L1 MEOX2 MOBP NTAQ1 RAB4B RGS17 SLITRK5 TK1 TXNRD3 XIAP ZFP90 ZNF177 ZNF511 ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF76 ZNF774
Entrez ID		79722	552900
HPRD ID		07758	18842
Ensembl ID		ENSG00000164512	ENSG00000183336
Uniprot IDs		Q3KP44	A0A087WZT3 Q9H3K6
PDB IDs
Enriched GO Terms of Interacting Partners?
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