CERS4 and JAGN1

Data Source:
BioGRID (two hybrid)

		CERS4	JAGN1
Description		ceramide synthase 4	jagunal homolog 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Protein Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Neutrophil Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Tunicamycin Neutrophil Migration
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		47 interacting genes: C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11A SMIM11B STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	126 interacting genes: AGPAT4 APP AQP6 ARL13B BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 C4orf3 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM199 TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VSIG4 VTI1B
Entrez ID		79603	84522
HPRD ID		13962	13749
Ensembl ID		ENSG00000090661	ENSG00000171135
Uniprot IDs		Q53HF9 Q9HA82	Q8N5M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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