ALG12 and RPL13A

Data Source:
BioGRID (two hybrid)

		ALG12	RPL13A
Description		ALG12 alpha-1,6-mannosyltransferase	ribosomal protein L13a
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol Alpha-1,6-mannosyltransferase	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Protein Folding Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Negative Regulation Of Translation Viral Transcription Cellular Response To Interferon-gamma Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes ALG12-CDG (CDG-1g)	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Acne (severe) ( 24927181) Platelet count ( 32888494) Platelet distribution width ( 32888494)	Hematological and biochemical traits ( 20139978)
Interacting Genes		2 interacting genes: PRDX4 RPL13A	14 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN
Entrez ID		79087	23521
HPRD ID		06189	11775
Ensembl ID		ENSG00000182858	ENSG00000142541
Uniprot IDs		A0A024R4V6 Q9BV10	A0A384ME37 P40429 Q8J015
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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