ALG12 and PRDX4

Data Source:
BioGRID (two hybrid)

		ALG12	PRDX4
Description		ALG12 alpha-1,6-mannosyltransferase	peroxiredoxin 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol Alpha-1,6-mannosyltransferase	Protein Binding Thioredoxin Peroxidase Activity
	Biological Process	Protein Folding Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes ALG12-CDG (CDG-1g)	Neutrophil degranulation
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Acne (severe) ( 24927181) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: PRDX4 RPL13A	25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		79087	10549
HPRD ID		06189	05935
Ensembl ID		ENSG00000182858	ENSG00000123131
Uniprot IDs		A0A024R4V6 Q9BV10	Q13162 V9HW63
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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