YWHAH and YWHAE

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD (in vivo)

		YWHAH	YWHAE
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Kinesin Complex Plasma Membrane Focal Adhesion Membrane Melanosome Extracellular Exosome Central Region Of Growth Cone Glutamatergic Synapse
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity	RNA Binding Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Enzyme Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ion Channel Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	G2/M Transition Of Mitotic Cell Cycle MAPK Cascade Regulation Of Heart Rate By Hormone Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Substantia Nigra Development Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs
Drugs		Phenethyl Isothiocyanate	Fusicoccin Phenethyl Isothiocyanate
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Atrial fibrillation ( 30061737) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)
Interacting Genes		66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	147 interacting genes: - ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCP2 MAGEB4 MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCOR2 NDEL1 NIN PAPOLA PARD3B PCM1 PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RPA2 RPGR RXFP3 SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAZ TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZC3HC1 ZNF839
Entrez ID		7533	7531
HPRD ID		00215	05457
Ensembl ID		ENSG00000128245	ENSG00000108953
Uniprot IDs		A0A024R1K7 Q04917 Q9H4N8	P62258 V9HW98
PDB IDs		2C63 2C74	2BR9 3UAL 3UBW 6EIH
Enriched GO Terms of Interacting Partners?
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