YWHAH and MED1

Data Source:
HPRD (in vitro)

		YWHAH	MED1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	mediator complex subunit 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Regulation Of Lipid Metabolic Process Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression
Drugs		Phenethyl Isothiocyanate	Becocalcidiol
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)
Interacting Genes		66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	46 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MAPK3 MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RBM5 RORA RPA2 RXRA SREBF1 TET2 THRA THRB TP53 VDR YWHAH YWHAQ
Entrez ID		7533	5469
HPRD ID		00215	05055
Ensembl ID		ENSG00000128245	ENSG00000125686
Uniprot IDs		A0A024R1K7 Q04917 Q9H4N8	Q15648
PDB IDs		2C63 2C74	1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6JEZ 6K5O 6ONJ
Enriched GO Terms of Interacting Partners?
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