XPNPEP1 and POLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XPNPEP1	POLA2
Description		X-prolyl aminopeptidase 1	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Aminopeptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity	Molecular_function DNA Binding Protein Binding
	Biological Process	Proteolysis Bradykinin Catabolic Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs			Dacarbazine
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 31043756 28072414) Refractive error ( 32231278)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		12 interacting genes: DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		7511	23649
HPRD ID		03899	10160
Ensembl ID		ENSG00000108039	ENSG00000014138
Uniprot IDs		Q5T6H7 Q9NQW7	Q14181
PDB IDs		3CTZ	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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