PCNA and DHX9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PCNA	DHX9
Description		proliferating cell nuclear antigen	DExH-box helicase 9
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome, Telomeric Region Chromatin Nucleus Nuclear Lamina Nucleoplasm Replication Fork Centrosome Nuclear Body Replisome Nuclear Replication Fork PCNA Complex Extracellular Exosome PCNA-p21 Complex	Intracellular Anatomical Structure Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Polysome Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Chromatin Binding Damaged DNA Binding Protein Binding Protein C-terminus Binding Enzyme Binding Estrogen Receptor Binding DNA Polymerase Processivity Factor Activity Receptor Tyrosine Kinase Binding Dinucleotide Insertion Or Deletion Binding MutLalpha Complex Binding Histone Acetyltransferase Binding Identical Protein Binding Protein-containing Complex Binding DNA Polymerase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding RNA Polymerase II Transcription Factor Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding ATPase Activity Nucleoside-triphosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity Importin-alpha Family Protein Binding RNA Polymerase Binding RISC Complex Binding Polysome Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Viral Process Protein Ubiquitination Translesion Synthesis Epithelial Cell Differentiation Replication Fork Processing Positive Regulation Of Deoxyribonuclease Activity Telomere Maintenance Via Semi-conservative Replication Response To Estradiol Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Estrous Cycle Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Response To Cadmium Ion Cellular Response To Hydrogen Peroxide Error-free Translesion Synthesis Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Liver Regeneration Positive Regulation Of DNA-directed DNA Polymerase Activity Response To L-glutamate Mitotic Telomere Maintenance Via Semi-conservative Replication	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation DNA Replication DNA-templated Transcription, Termination Regulation Of Transcription By RNA Polymerase II Inflammatory Response RNA Secondary Structure Unwinding Targeting Of MRNA For Destruction Involved In RNA Interference Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Protein-containing Complex Assembly DNA-templated Viral Transcription G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Pyroptosis Small RNA Loading Onto RISC CRD-mediated MRNA Stabilization Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Viral Translation Positive Regulation Of Polysome Binding Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Gene Silencing By MiRNA Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Transcription of E2F targets under negative control by DREAM complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand SUMOylation of DNA replication proteins Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription E3 ubiquitin ligases ubiquitinate target proteins	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway
Drugs		Liothyronine Acetylsalicylic acid
Diseases
GWAS
Interacting Genes		139 interacting genes: ALDOA APEX1 APEX2 ATAD5 BAZ1B CBX1 CCNB1 CCND1 CCND3 CCNO CDC25C CDC6 CDK1 CDK2 CDK5 CDK6 CDKN1A CDKN1C CDKN2A CDT1 CHAF1A CHTF18 CHTF8 CMTM5 CREBBP DHX9 DNMT1 DNTT DNTTIP2 DSCC1 DTL EGFR ENO1 EP300 ERCC5 ERCC6 ERRFI1 ESCO2 EXO1 FAN1 FANCD2 FANCL FEN1 GADD45A GADD45B GADD45G GAPDH GCK GPI HDAC1 HUS1 HUWE1 IGF1R ING1 KCTD13 KMT5A LDHA LIG1 LMNA MCL1 MGMT MLH1 MSH2 MSH3 MSH6 MUTYH MYBBP1A NMRAL1 NSD2 NTHL1 NUTF2 PARP1 PARP10 PARPBP PCLAF PFKM PGAM1 PGK1 PKLR PMS2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLE POLH POLI POLK POLL POLM PPP1CA PRKDC PTEN PTMA RAD18 RAD9A RBBP8 RFC1 RFC2 RFC3 RFC4 RFC5 RFWD3 RNF8 RPA1 SDE2 SEC23IP SIVA1 SLC30A8 SMARCAD1 SPG21 SUB1 SUMO1 TCOF1 TDG TIRAP TMEM218 TPI1 TRIM28 UBB UBE2A UBE2B UBE2D3 UHRF1 UNG USP1 USP2 USP4 WDR48 WRN WRNIP1 XPA XRCC1 XRCC5 XRCC6 YBX1 ZBTB1	43 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 DUX4 EIF2AK2 ESR1 GEMIN2 GEMIN4 GTF2B H2AX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01554 MBD2 NXF1 OGA PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ
Entrez ID		5111	1660
HPRD ID		01456	04386
Ensembl ID		ENSG00000132646	ENSG00000135829
Uniprot IDs		P12004	B3KU66 Q08211
PDB IDs		1AXC 1U76 1U7B 1UL1 1VYJ 1VYM 1W60 2ZVK 2ZVL 2ZVM 3JA9 3P87 3TBL 3VKX 3WGW 4D2G 4RJF 4ZTD 5E0T 5E0U 5E0V 5IY4 5MAV 5MLO 5MLW 5MOM 5YCO 5YD8 6CBI 6EHT 6FCM 6FCN 6GIS 6GWS 6HVO 6K3A 6QC0 6QCG 6S1M 6S1N 6S1O 6TNY 6TNZ 6VVO	3LLM 3VYX 3VYY
Enriched GO Terms of Interacting Partners?
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