WNT2B and RAD21

Data Source:
BioGRID (two hybrid)

		WNT2B	RAD21
Description		Wnt family member 2B	RAD21 cohesin complex component
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Frizzled Binding Cytokine Activity	Chromatin Binding Protein Binding
	Biological Process	Chondrocyte Differentiation Lens Development In Camera-type Eye Male Gonad Development Cellular Response To Starvation Wnt Signaling Pathway Forebrain Regionalization Neuron Differentiation Cell Fate Commitment Canonical Wnt Signaling Pathway Lung Induction Mesenchymal-epithelial Cell Signaling Iris Morphogenesis Cornea Development In Camera-type Eye Hematopoietic Stem Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 29403010 30487518) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549 28869591) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pancreatic cancer ( 29422604 26098869) Potassium levels ( 29403010) Pulse pressure ( 30487518) Stroke ( 29531354) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 29403010 30487518 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Menopause (age at onset) ( 29773799)
Interacting Genes		2 interacting genes: BRCA1 RAD21	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		7482	5885
HPRD ID		03574	05924
Ensembl ID		ENSG00000134245	ENSG00000164754
Uniprot IDs		Q5TEH8 Q93097	A0A024R9J0 O60216
PDB IDs			4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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