UGP2 and ARIH2

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		UGP2	ARIH2
Description		UDP-glucose pyrophosphorylase 2	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Brain Development	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Formation of the active cofactor, UDP-glucuronate Glycogen synthesis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Smoking initiation (ever regular vs never regular) ( 30679032) Systolic blood pressure ( 26969751)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		7 interacting genes: ABCA1 ARIH2 CBS GLRX3 PCBP1 PLEKHF2 TTN	50 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 PAX6 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		7360	10425
HPRD ID		08934	09286
Ensembl ID		ENSG00000169764	ENSG00000177479
Uniprot IDs		A0A140VKE1 Q16851	O95376 Q53ET9 Q6IBL8
PDB IDs		3R2W 3R3I 4R7P
Enriched GO Terms of Interacting Partners?
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