ARIH2 and CBR3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARIH2	CBR3
Description		ariadne RBR E3 ubiquitin protein ligase 2	carbonyl reductase 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Extracellular Space Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Phase I - Functionalization of compounds
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		50 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 PAX6 PHF7 PPP2R1A PTN REL RHEB RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91	5 interacting genes: ARIH2 BICD2 RAB35 SDCBP UBC
Entrez ID		10425	874
HPRD ID		09286	07222
Ensembl ID		ENSG00000177479	ENSG00000159231
Uniprot IDs		O95376 Q53ET9 Q6IBL8	O75828 V9HW40
PDB IDs			2HRB
Enriched GO Terms of Interacting Partners?
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