UBE2A and RNF40

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		UBE2A	RNF40
Description		ubiquitin conjugating enzyme E2 A	ring finger protein 40
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleoplasm Cytosol HULC Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Membrane Extrinsic Component Of Membrane HULC Complex Neuron Projection Axon Terminus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Syntaxin-1 Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Protein Ubiquitination Histone H2B Ubiquitination Response To Peptide Hormone Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Histone H2B Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Brain connectivity ( 23471985)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2	26 interacting genes: AMOTL2 ATM CCDC146 CDC73 DISC1 DUSP29 EEF1D ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL RB1 RNF20 SFR1 TRIM51 UBE2A UBE2B UBE2D2 UBE2E1 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		7319	9810
HPRD ID		02422	07411
Ensembl ID		ENSG00000077721	ENSG00000103549
Uniprot IDs		A0A0D9SG71 P49459	A8K6K1 O75150
PDB IDs		6CYO 6CYR
Enriched GO Terms of Interacting Partners?
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