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TWIST1 and TRIM28
Data Source:
BioGRID
(affinity chromatography technology, pull down)
TWIST1
TRIM28
Description
twist family bHLH transcription factor 1
tripartite motif containing 28
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
BHLH Transcription Factor Binding
E-box Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Krueppel-associated Box Domain Binding
Chromo Shadow Domain Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Osteoblast Differentiation
In Utero Embryonic Development
Neuron Migration
Neural Tube Closure
Aortic Valve Morphogenesis
Mitral Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Muscle Organ Development
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Regulation Of Bone Mineralization
Positive Regulation Of Fatty Acid Beta-oxidation
Developmental Process
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Histone Phosphorylation
Negative Regulation Of Histone Acetylation
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Outer Ear Morphogenesis
Odontogenesis
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Negative Regulation Of Skeletal Muscle Tissue Development
Embryonic Cranial Skeleton Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Roof Of Mouth Development
Cranial Suture Morphogenesis
Embryonic Camera-type Eye Formation
Eyelid Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Cellular Response To Hypoxia
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of DNA-templated Transcription, Initiation
Positive Regulation Of Cell Motility
Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Cellular Senescence
Negative Regulation Of Double-strand Break Repair
Cell Proliferation Involved In Heart Valve Development
Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation
Negative Regulation Of Transcription By RNA Polymerase II
Epithelial To Mesenchymal Transition
DNA Repair
Chromatin Organization
Transcription Initiation From RNA Polymerase II Promoter
Ras Protein Signal Transduction
Embryo Implantation
Viral Process
Protein Ubiquitination
Protein Sumoylation
Positive Regulation Of Protein Import Into Nucleus
DNA Methylation Involved In Embryo Development
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of DNA Repair
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Convergent Extension Involved In Axis Elongation
Embryonic Placenta Morphogenesis
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Negative Regulation Of DNA Demethylation
Negative Regulation Of Viral Release From Host Cell
Regulation Of Genetic Imprinting
Pathways
Interleukin-4 and Interleukin-13 signaling
Transcriptional regulation by RUNX2
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Generic Transcription Pathway
SUMOylation of transcription cofactors
HCMV Early Events
Drugs
Diseases
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS
Coronary artery disease (
32469254
30104761
33020668
)
Diastolic blood pressure (
30578418
)
Diisocyanate-induced asthma (
25918132
)
Ischemic stroke (
29531354
)
Ischemic stroke (large artery atherosclerosis) (
29531354
)
Large artery stroke (CCS and TOAST classification) (
32047268
)
Large artery stroke (CCS or TOAST classification) (
32047268
)
Large artery stroke (CCSp classification)j (
32047268
)
Large artery stroke (TOAST classification) (
32047268
)
Male-pattern baldness (
29146897
)
Night sleep phenotypes (
27126917
)
Obesity-related traits (
23251661
)
Pulse pressure (
27841878
29403010
30487518
30578418
)
Stroke (
29531354
)
Systolic blood pressure (
27841878
30487518
30578418
)
Type 2 diabetes (age of onset) (
28060188
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
25 interacting genes:
BCL6
CHD4
EP300
GLI3
HOXA5
IKBKB
KAT2B
KMT5A
KPNA5
KPNA7
MYOD1
NEIL3
PTEN
RBBP7
RELA
STAT3
TCF3
TCF4
TP53
TRIB3
TRIM28
YY1
YY2
ZIC3
ZRANB1
76 interacting genes:
CBX1
CBX3
CBX5
CDC34
CDC42
CDCA4
CDKN2A
CEBPB
CHAF1A
CHD3
ESR1
FBP1
FES
HDAC10
HTRA2
IRF1
IRF7
LYN
MAGEA2
MAGEA2B
MAGEA6
MAGED1
MAPKAPK2
MCM3
MCM5
MCM6
MYB
NPM1
NR3C1
NR4A1
NR4A3
NSMCE3
PCNA
PFDN5
PPP2CA
PTEN
RFC4
RNF4
SERTAD1
SERTAD2
SETDB1
SIN3A
SIRT1
SKI
SMARCAD1
SPG7
STAT3
SUMO2
TP73
TRIM24
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
VHL
VIM
YWHAQ
ZNF10
ZNF133
ZNF140
ZNF197
ZNF354A
ZNF382
ZNF420
ZNF496
ZNF689
ZNF74
ZNF93
Entrez ID
7291
10155
HPRD ID
03374
03445
Ensembl ID
ENSG00000122691
ENSG00000130726
Uniprot IDs
Q15672
Q13263
PDB IDs
2MJV
1FP0
2RO1
2YVR
6H3A
6I9H
6QAJ
6QU1
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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