TRIM28 and HDAC10

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TRIM28	HDAC10
Description		tripartite motif containing 28	histone deacetylase 10
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Deacetylase Activity Enzyme Binding Protein Deacetylase Activity Histone Deacetylase Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Ras Protein Signal Transduction Embryo Implantation Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus DNA Methylation Involved In Embryo Development Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Regulation Of Transcription, DNA-templated Protein Deacetylation Oligodendrocyte Development Macroautophagy Histone Deacetylation Positive Regulation Of Mismatch Repair Peptidyl-lysine Deacetylation Homologous Recombination Negative Regulation Of Transcription, DNA-templated Polyamine Deacetylation Spermidine Deacetylation
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs			Belinostat Panobinostat Bufexamac
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		76 interacting genes: CBX1 CBX3 CBX5 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 ESR1 FBP1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA6 MAGED1 MAPKAPK2 MCM3 MCM5 MCM6 MYB NPM1 NR3C1 NR4A1 NR4A3 NSMCE3 PCNA PFDN5 PPP2CA PTEN RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93	9 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54
Entrez ID		10155	83933
HPRD ID		03445	09407
Ensembl ID		ENSG00000130726	ENSG00000100429
Uniprot IDs		Q13263	Q969S8
PDB IDs		1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1
Enriched GO Terms of Interacting Partners?
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