C4A and CR1

Data Source:
HPRD (in vitro)

		C4A	CR1
Description		complement C4A (Rodgers blood group)	complement C3b/C4b receptor 1 (Knops blood group)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle	Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Complement Component C1q Complex Binding Endopeptidase Inhibitor Activity	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity Protein Binding
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Neutrophil Degranulation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Cytolysis Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation ATP Export
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade	Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade
Drugs		Human immunoglobulin G
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)	Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)
Interacting Genes		7 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 MASP2	6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		720	1378
HPRD ID		00401	00398
Ensembl ID		ENSG00000244731	ENSG00000203710
Uniprot IDs		P0C0L4	E9PDY4 P17927
PDB IDs		1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW	1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9
Enriched GO Terms of Interacting Partners?
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