C4A and MASP2

Data Source:
BioGRID (enzymatic study)

		C4A	MASP2
Description		complement C4A (Rodgers blood group)	MBL associated serine protease 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Endopeptidase Inhibitor Activity	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs		Human immunoglobulin G	beta-Hydroxyasparagine
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus	Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)	Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)
Interacting Genes		7 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3 MASP2	4 interacting genes: C4A FCN2 MBL2 SERPING1
Entrez ID		720	10747
HPRD ID		00401	05484
Ensembl ID		ENSG00000244731	ENSG00000009724
Uniprot IDs		P0C0L4	O00187
PDB IDs		1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW	1Q3X 1SZB 1ZJK 3TVJ 4FXG 5JPM
Enriched GO Terms of Interacting Partners?
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