C3 and CFB

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		C3	CFB
Description		complement C3	complement factor B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding	Complement Binding Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Neuron Remodeling Regulation Of Complement Activation Oviduct Epithelium Development Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Immune Response Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Apoptotic Cell Clearance	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation
Pathways		Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade
Drugs		Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488) Complement C3 and C4 levels ( 23028341) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		36 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4	5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2
Entrez ID		718	629
HPRD ID		00400	00718
Ensembl ID		ENSG00000125730	ENSG00000243649
Uniprot IDs		B4DR57 P01024 V9HWA9	A0A1U9X7H8 P00751
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RUR 6RUV 6S0B	1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV 6T8U 6T8V 6T8W
Enriched GO Terms of Interacting Partners?
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