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C3
Description
complement C3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Cell Surface
Protein-containing Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Extracellular Exosome
Blood Microparticle
Molecular Function
Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
C5L2 Anaphylatoxin Chemotactic Receptor Binding
Biological Process
Positive Regulation Of Type IIa Hypersensitivity
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Activation Of Membrane Attack Complex
Fatty Acid Metabolic Process
Inflammatory Response
Immune Response
Complement Activation
Complement Activation, Alternative Pathway
Complement Activation, Classical Pathway
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Response To Bacterium
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Glucose Transmembrane Transport
Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Lipid Storage
Negative Regulation Of Endopeptidase Activity
Neuron Remodeling
Regulation Of Complement Activation
Oviduct Epithelium Development
Neutrophil Degranulation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Immune Response
Positive Regulation Of Phagocytosis, Engulfment
Amyloid-beta Clearance
Complement-dependent Cytotoxicity
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Positive Regulation Of Apoptotic Cell Clearance
Pathways
Alternative complement activation
Activation of C3 and C5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Neutrophil degranulation
Post-translational protein phosphorylation
Purinergic signaling in leishmaniasis infection
Regulation of Complement cascade
Drugs
Human immunoglobulin G
Zinc
S-Hydroxycysteine
Mirococept
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385819
20385826
23455636
20861866
21665990
)
Age-related macular degeneration (choroidal neovascularisation) (
22705344
)
Age-related macular degeneration (geographic atrophy) (
22705344
)
Blood protein levels (
30072576
29875488
)
Complement C3 and C4 levels (
23028341
)
Disease progression in age-related macular degeneration (
29346644
)
Early age-related macular degeneration (
32843070
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
)
Triglycerides (
24097068
)
White blood cell count (
32888494
)
Novel Interacting Genes
1 novel interacting genes:
ICAM3
Interacting Genes
36 interacting genes:
ABL1
AGR2
ATG16L1
C2
C3AR1
C5
C5AR2
CD46
CFB
CFH
CFHR3
CFHR4
CFHR5
CFI
CFP
CPN1
CR1
CR2
CTSG
EFEMP2
GC
GOLGA6L9
HMGB1
ITGAM
ITGAX
ITGB2
KRT31
KRTAP10-8
LAMA1
LRP1
MASP1
OLFM4
PAPPA
PLEKHF2
TGM2
VSIG4
Entrez ID
718
HPRD ID
00400
Ensembl ID
ENSG00000125730
Uniprot IDs
B4DR57
P01024
V9HWA9
PDB IDs
1C3D
1GHQ
1W2S
2A73
2A74
2GOX
2I07
2ICE
2ICF
2NOJ
2QKI
2WII
2WIN
2WY7
2WY8
2XQW
2XWB
2XWJ
3D5R
3D5S
3G6J
3L3O
3L5N
3NMS
3OED
3OHX
3OXU
3RJ3
3T4A
4HW5
4HWJ
4I6O
4M76
4ONT
4ZH1
5FO7
5FO8
5FO9
5FOA
5FOB
5NBQ
5O32
5O35
6EHG
6RUR
6RUV
6S0B
Enriched GO Terms of Interacting Partners
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