TNFAIP3 and GIT2

Data Source:
BioGRID (two hybrid)

		TNFAIP3	GIT2
Description		TNF alpha induced protein 3	GIT ArfGAP 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome	Nucleoplasm Focal Adhesion
	Molecular Function	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Cysteine-type Peptidase Activity Zinc Ion Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Lys63-specific Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Protein K33-linked Deubiquitination Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25903422 20953190 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 30423114 23143596 24390342 20453841 20453842 17982456) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) SjÃ¶gren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 27182965 28928442)	Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		47 interacting genes: ARRDC3 CCDC50 CHUK GAS8 GIT2 GSK3B IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PFKL PIBF1 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 SNAI1 TAX1BP1 TICAM1 TNIP1 TNIP2 TNIP3 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5	48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		7128	9815
HPRD ID		01857	09779
Ensembl ID		ENSG00000118503	ENSG00000139436
Uniprot IDs		P21580	F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58
PDB IDs		2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P
Enriched GO Terms of Interacting Partners?
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