TM7SF2 and RAP2A

Data Source:
BioGRID (two hybrid)

		TM7SF2	RAP2A
Description		transmembrane 7 superfamily member 2	RAP2A, member of RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Receptor Complex	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity NADP Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Blood protein levels ( 28240269)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		4 interacting genes: CHRM4 CYSRT1 LCE2C RAP2A	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		7108	5911
HPRD ID		04564	01547
Ensembl ID		ENSG00000149809	ENSG00000125249
Uniprot IDs		A0A024R577 O76062	P10114
PDB IDs			1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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