TLR5 and TLR1

Data Source:
HPRD (in vitro)

		TLR5	TLR1
Description		toll like receptor 5	toll like receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Defense Response To Bacterium Innate Immune Response Cellular Response To Mechanical Stimulus	Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Innate Immune Response Cellular Response To Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs
Diseases		Systemic lupus erythematosus
GWAS		Monocyte percentage of white cells ( 32888494)	Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4	9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1
Entrez ID		7100	7096
HPRD ID		04326	03119
Ensembl ID		ENSG00000187554	ENSG00000174125
Uniprot IDs		A0A2R8Y7Z4 O60602	Q15399
PDB IDs		1P95 3J0A	1FYV 2Z7X 6NIH
Enriched GO Terms of Interacting Partners?
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