TLR5 and SIGIRR

Data Source:
HPRD (in vivo)

		TLR5	SIGIRR
Description		toll like receptor 5	single Ig and TIR domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Defense Response To Bacterium Innate Immune Response Cellular Response To Mechanical Stimulus	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Cytokine Stimulus
Pathways		Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling
Drugs
Diseases		Systemic lupus erythematosus
GWAS		Monocyte percentage of white cells ( 32888494)	Apolipoprotein A1 levels ( 32203549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4	9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6
Entrez ID		7100	59307
HPRD ID		04326	12018
Ensembl ID		ENSG00000187554	ENSG00000185187
Uniprot IDs		A0A2R8Y7Z4 O60602	C9JFX4 Q6IA17
PDB IDs		1P95 3J0A
Enriched GO Terms of Interacting Partners?
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