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THRA and NCOR1
Data Source:
BioGRID
(pull down, affinity chromatography technology, pull down, two hybrid, pull down)
HPRD
(two hybrid)
THRA
NCOR1
Description
thyroid hormone receptor alpha
nuclear receptor corepressor 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Sin3 Complex
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Thyroid Hormone Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
Thyroid Hormone Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cartilage Condensation
Ossification
Thyroid Hormone Mediated Signaling Pathway
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Cell Differentiation
Erythrocyte Differentiation
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of DNA-templated Transcription, Initiation
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Circadian Rhythm
Regulation Of Lipid Metabolic Process
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways
Nuclear Receptor transcription pathway
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Liothyronine
Levothyroxine
Dextrothyroxine
Amiodarone
Liotrix
KB-141
Dronedarone
Eprotirome
NRP409
Thyroid, porcine
Diseases
GWAS
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Chronic obstructive pulmonary disease (
30804561
)
Pancreatic ductal adenocarcinoma (
30541042
)
White blood cell count (
21738480
)
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
69 interacting genes:
-
AKAP13
AMOT
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CD160
CDK7
CEP76
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
MEOX2
MTNR1B
NCOA1
NCOA2
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKAR1B
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SELENOP
SLC16A2
SRC
SUV39H1
SYAP1
TACC1
TBL1X
TDG
TRIM24
TRIM63
TRIP11
TXNRD1
UBE2I
YWHAH
YWHAQ
ZBTB3
89 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
PDCD2
PHB
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB7A
ZMYND11
Entrez ID
7067
9611
HPRD ID
07185
02911
Ensembl ID
ENSG00000126351
ENSG00000141027
Uniprot IDs
P10827
Q6FH41
A0A024RD47
O75376
Q6PGR4
PDB IDs
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
4LNW
4LNX
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
Enriched GO Terms of Interacting Partners
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