THRA and RGN

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		THRA	RGN
Description		thyroid hormone receptor alpha	regucalcin
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding	Gluconolactonase Activity Calcium Ion Binding Zinc Ion Binding Enzyme Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation	Kidney Development Negative Regulation Of Protein Kinase Activity Cellular Calcium Ion Homeostasis Spermatogenesis Aging Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Phosphatase Activity L-ascorbic Acid Biosynthetic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of ATPase Activity Negative Regulation Of GTPase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Calcium-mediated Signaling Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Liver Regeneration Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Bone Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Calcium-dependent ATPase Activity Negative Regulation Of DNA Catabolic Process Positive Regulation Of DUTP Diphosphatase Activity Negative Regulation Of Leucine-tRNA Ligase Activity Negative Regulation Of DNA Biosynthetic Process
Pathways		Nuclear Receptor transcription pathway
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		69 interacting genes: - AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3	2 interacting genes: NR1D2 THRA
Entrez ID		7067	9104
HPRD ID		07185	02196
Ensembl ID		ENSG00000126351	ENSG00000130988
Uniprot IDs		P10827 Q6FH41	Q15493 V9HWF8
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX	3G4E 3G4H 4GNB 4GNC
Enriched GO Terms of Interacting Partners?
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