VPS72 and TET2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		VPS72	TET2
Description		vacuolar protein sorting 72 homolog	tet methylcytosine dioxygenase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex	Nucleus
	Molecular Function	DNA Binding Protein Binding Histone Binding	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Population Maintenance Histone Exchange	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways		HATs acetylate histones	TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)
Interacting Genes		9 interacting genes: CALCOCO2 CCDC85B EWSR1 HMBOX1 HSF2BP MDFI PRMT1 STK11 TET2	19 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS72 ZCCHC14 ZNF207
Entrez ID		6944	54790
HPRD ID		02791	07876
Ensembl ID		ENSG00000163159	ENSG00000168769
Uniprot IDs		Q15906	A0A024RDF7 A0A158SIU0 Q6N021
PDB IDs		5FUG	4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
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