SVIL and HMMR

Data Source:
BioGRID (two hybrid)

		SVIL	HMMR
Description		supervillin	hyaluronan mediated motility receptor
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere	Centrosome Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Protein Binding Hyaluronic Acid Binding
	Biological Process	Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping	Regulation Of G2/M Transition Of Mitotic Cell Cycle Hyaluronan Catabolic Process
Pathways			Hyaluronan uptake and degradation AURKA Activation by TPX2
Drugs			Hyaluronic acid
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		35 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	16 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TRIM54 TUBB2A
Entrez ID		6840	3161
HPRD ID		04992	02963
Ensembl ID		ENSG00000197321	ENSG00000072571
Uniprot IDs		A0A6I8PIX7 O95425 Q569J5	O75330
PDB IDs		2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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