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STAT5B and CXCR4
Data Source:
HPRD
(in vivo)
STAT5B
CXCR4
Description
signal transducer and activator of transcription 5B
C-X-C motif chemokine receptor 4
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Lysosome
Early Endosome
Late Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Cell Junction
Cell Leading Edge
Cytoplasmic Vesicle
Protein-containing Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Dimerization Activity
Virus Receptor Activity
Actin Binding
G Protein-coupled Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
C-C Chemokine Binding
Ubiquitin Protein Ligase Binding
Myosin Light Chain Binding
C-X-C Motif Chemokine 12 Receptor Activity
Identical Protein Binding
Ubiquitin Binding
Biological Process
Luteinization
Natural Killer Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-4
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Activation Of MAPK Activity
Response To Hypoxia
Neuron Migration
Epithelial Cell Development
Dendritic Cell Chemotaxis
Apoptotic Process
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Axon Guidance
Brain Development
Neuron Recognition
Response To Virus
Response To Activity
Fusion Of Virus Membrane With Host Plasma Membrane
Calcium-mediated Signaling
Neurogenesis
Telencephalon Cell Migration
Regulation Of Cell Adhesion
Positive Regulation Of Vascular Wound Healing
Cellular Response To Drug
CXCL12-activated CXCR4 Signaling Pathway
Regulation Of Programmed Cell Death
Myelin Maintenance
Response To Morphine
Endothelial Cell Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Viral Process
Regulation Of Chemotaxis
Positive Regulation Of Chemotaxis
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Regulation Of Calcium Ion Transport
Cardiac Muscle Contraction
Cell Chemotaxis
Endothelial Tube Morphogenesis
Cellular Response To Cytokine Stimulus
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Dendrite Extension
Positive Regulation Of Mesenchymal Stem Cell Migration
Response To Ultrasound
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Growth hormone receptor signaling
Growth hormone receptor signaling
Binding and entry of HIV virion
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Dasatinib
Framycetin
AMD-070
Plerixafor
Ibalizumab
Diseases
Growth hormone insensitivity with immunodeficiency
Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
32296059
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
27569725
28067908
23128233
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Albumin-globulin ratio (
29403010
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Arthritis (juvenile idiopathic) (
27005825
)
Attention deficit hyperactivity disorder (
32595297
)
Body mass index (
26426971
)
Colorectal cancer (
29228715
)
Estimated glomerular filtration rate (
31152163
)
Lung function (low FEV1 vs high FEV1) (
26423011
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Multiple sclerosis (
31604244
19525953
)
Non-albumin protein levels (
29403010
)
Smoking status (ever vs never smokers) (
30643258
)
Telomere length (
20421499
)
White blood cell count (
32888494
)
Interacting Genes
62 interacting genes:
AFTPH
APP
CBL
CD247
CDKN1A
CENPJ
CHAF1A
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
MRPS6
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
34 interacting genes:
ARRB2
ATP13A2
B2M
CCR5
CD4
CTSG
CXCL12
DPP4
DUXAP9
ELANE
GNA13
GNAI1
GRK3
HSPA8
ITCH
JAK1
JAK2
JAK3
MYBL2
MYH9
PTK2
PTPN11
PTPN6
PTPRC
RNF113A
SDC4
SOCS1
SOCS3
STAT1
STAT2
STAT3
STAT5B
USP14
VAV1
Entrez ID
6777
7852
HPRD ID
05037
01217
Ensembl ID
ENSG00000173757
ENSG00000121966
Uniprot IDs
P51692
A0A0U3FJG0
A0A0U3GXA9
P61073
PDB IDs
6MBW
6MBZ
2K03
2K04
2K05
2N55
3ODU
3OE0
3OE6
3OE8
3OE9
4RWS
Enriched GO Terms of Interacting Partners
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