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STAT5B and ETS1
Data Source:
HPRD
(in vivo, in vitro)
STAT5B
ETS1
Description
signal transducer and activator of transcription 5B
ETS proto-oncogene 1, transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Dimerization Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Biological Process
Luteinization
Natural Killer Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-4
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Immune Response
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Mechanical Stimulus
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Hypothalamus Development
Pituitary Gland Development
Cell Differentiation
PML Body Organization
Response To Estradiol
Response To Laminar Fluid Shear Stress
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Estrous Cycle
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Motility
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cellular Component Movement
Angiogenesis Involved In Wound Healing
Cellular Response To Hydrogen Peroxide
Response To Interleukin-1
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Growth hormone receptor signaling
Growth hormone receptor signaling
Oncogene Induced Senescence
Drugs
Dasatinib
Diseases
Growth hormone insensitivity with immunodeficiency
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
32296059
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
27569725
28067908
23128233
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Adverse response to drug (
30420678
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Atopic dermatitis (
26482879
)
Celiac disease (
22057235
20190752
25920553
30572963
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Depressive and manic episodes in bipolar disorder (
26297903
)
Depressive episodes in bipolar disorder (
26297903
)
Eczema (
31361310
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Follicular lymphoma (
25279986
)
Glaucoma (
31959993
30054594
)
Glaucoma (multi-trait analysis) (
31959993
)
Granulocyte count (
27863252
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Itch intensity from mosquito bite (
28199695
)
Liver fibrosis in pediatric non-alcoholic fatty acid liver disease (
28918882
)
Lung function (FVC) (
30061609
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Manganese levels (
26025379
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
32888494
27863252
)
Mosquito bite size (
28199695
)
Multiple sclerosis (
31604244
24076602
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Psoriasis (
25903422
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
22446963
24390342
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Self-reported allergy (
23817569
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
23273568
26663301
26502338
20169177
28714469
19838193
)
Type 2 diabetes (
30054458
30297969
30718926
)
Ulcerative colitis (
28067908
)
White blood cell count (
32888494
27863252
)
Interacting Genes
62 interacting genes:
AFTPH
APP
CBL
CD247
CDKN1A
CENPJ
CHAF1A
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
MRPS6
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
50 interacting genes:
APLP2
APP
ARID4B
ARL6IP4
ATF2
BRCA1
CAMK2A
CAMK2B
COP1
CREBBP
CYBC1
DAXX
DNMT3L
EIF5B
EP300
ETS2
FOS
GATA3
HTATIP2
JUN
MAF
MAPK1
MAPK3
MAPK7
MED23
MEIS1
NCL
NCOR1
NFKB1
NR3C1
PARP1
PAX5
POU1F1
RBBP6
RPL13A
RUNX1T1
RUNX2
SMAD3
SP1
SP100
SPI1
SRA1
SRC
SRSF11
STAT5B
STAT6
TBP
TDP2
UBE2I
XRCC6
Entrez ID
6777
2113
HPRD ID
05037
01260
Ensembl ID
ENSG00000173757
ENSG00000134954
Uniprot IDs
P51692
A8K725
B4DW78
P14921
PDB IDs
6MBW
6MBZ
1GVJ
2NNY
2STT
2STW
3MFK
3RI4
3WTS
3WTT
3WTU
3WTV
3WTW
3WTX
3WTY
3WTZ
3WU0
3WU1
4L0Y
4L0Z
4L18
4LG0
5ZMC
Enriched GO Terms of Interacting Partners
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