BRCA2 and CCNA1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		BRCA2	CCNA1
Description		BRCA2 DNA repair associated	cyclin A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Centrosome Cytosol Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Protein C-terminus Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication Establishment Of Protein Localization To Telomere Mitotic Recombination-dependent Replication Fork Processing	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Protein Deubiquitination Mitotic Cell Cycle Phase Transition Cell Division
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination	G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases		Fanconi anemia Pancreatic cancer Breast cancer Ovarian cancer
GWAS		Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 23535729 23535733) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)	Cocaine dependence ( 31212010) Nickel levels ( 26025379)
Interacting Genes		49 interacting genes: ATM ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 NEDD4 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1	35 interacting genes: ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6
Entrez ID		675	8900
HPRD ID		02554	04946
Ensembl ID		ENSG00000139618	ENSG00000133101
Uniprot IDs		P51587	A0A140VJG0 P78396
PDB IDs		1N0W 3EU7 6GY2 6HQU
Enriched GO Terms of Interacting Partners?
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