SRD5A2 and GNMT

Data Source:
BioGRID (two hybrid)

		SRD5A2	GNMT
Description		steroid 5 alpha-reductase 2	glycine N-methyltransferase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Sterol 5-alpha Reductase Activity Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Cholestenone 5-alpha-reductase Activity	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Cell-cell Signaling Androgen Metabolic Process Male Gonad Development Cell Differentiation Male Genitalia Development Testosterone Biosynthetic Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		Androgen biosynthesis	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs		Spironolactone Azelaic acid Dutasteride Finasteride	Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Idiopathic pulmonary fibrosis ( 29066090) Inflammatory biomarkers ( 24182552) Male-pattern baldness ( 29146897 27182965 28196072) Zinc levels ( 26025379)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		2 interacting genes: CYSRT1 GNMT	30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		6716	27232
HPRD ID		07390	05970
Ensembl ID		ENSG00000277893	ENSG00000124713
Uniprot IDs		P31213	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs		7BW1	1R74 2AZT
Enriched GO Terms of Interacting Partners?
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