SRD5A2

Description		steroid 5 alpha-reductase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Sterol 5-alpha Reductase Activity Oxidoreductase Activity Testosterone Dehydrogenase [NAD(P)] Activity Cholestenone 5-alpha-reductase Activity
	Biological Process	Steroid Biosynthetic Process Androgen Biosynthetic Process Cell-cell Signaling Androgen Metabolic Process Male Gonad Development Cell Differentiation Male Genitalia Development Testosterone Biosynthetic Process
Pathways		Androgen biosynthesis
Drugs		Spironolactone Azelaic acid Dutasteride Finasteride
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Idiopathic pulmonary fibrosis ( 29066090) Inflammatory biomarkers ( 24182552) Male-pattern baldness ( 29146897 27182965 28196072) Zinc levels ( 26025379)
Novel Interacting Genes		2 novel interacting genes: ATP5MG NCOA1
Interacting Genes		2 interacting genes: CYSRT1 GNMT
Entrez ID		6716
HPRD ID		07390
Ensembl ID		ENSG00000277893
Uniprot IDs		P31213
PDB IDs		7BW1
Enriched GO Terms of Interacting Partners?
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