SPTAN1 and SPTBN1

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo, in vitro)

		SPTAN1	SPTBN1
Description		spectrin alpha, non-erythrocytic 1	spectrin beta, non-erythrocytic 1
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GO Annotations	Cellular Component	Extracellular Region Cytosol Spectrin Microtubule Cytoskeleton Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Cadherin Binding GTPase Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Neutrophil Degranulation Actin Filament Capping	MAPK Cascade Mitotic Cytokinesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Cytoskeleton Organization Axon Guidance Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport	Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs			Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 ZNF333	49 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B
Entrez ID		6709	6711
HPRD ID		01684	01683
Ensembl ID		ENSG00000197694	ENSG00000115306
Uniprot IDs		A0A384P5S9 Q13813	B2ZZ89 Q01082
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?
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