SPTAN1 and CNTRL

Data Source:
BioGRID (genetic interference)

		SPTAN1	CNTRL
Description		spectrin alpha, non-erythrocytic 1	centriolin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Spectrin Microtubule Cytoskeleton Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Centrosome Microtubule Organizing Center Cytosol Membrane Perinuclear Region Of Cytoplasm Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	Protein Binding Cytoskeletal Protein Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Neutrophil Degranulation Actin Filament Capping	G2/M Transition Of Mitotic Cell Cycle Kidney Development Ventricular Septum Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Aorta Development Cell Division Regulation Of Cytoskeleton Organization Coronary Vasculature Development Ciliary Basal Body-plasma Membrane Docking
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Pulse pressure ( 27841878)
Interacting Genes		56 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 ZNF333	3 interacting genes: MAP3K4 MAPK6 TRADD
Entrez ID		6709	11064
HPRD ID		01684	05691
Ensembl ID		ENSG00000197694	ENSG00000119397
Uniprot IDs		A0A384P5S9 Q13813	B2RP65 Q7Z7A1
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?
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