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SOX9 and CREB1
Data Source:
HPRD
(in vivo)
SOX9
CREB1
Description
SRY-box transcription factor 9
cAMP responsive element binding protein 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Protein Kinase A Catalytic Subunit Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Pre-mRNA Intronic Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Cartilage Condensation
Ossification
Branching Involved In Ureteric Bud Morphogenesis
Cell Fate Specification
Epithelial To Mesenchymal Transition
Tissue Homeostasis
Positive Regulation Of Protein Phosphorylation
Hair Follicle Development
Morphogenesis Of An Epithelium
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Negative Regulation Of Immune System Process
Heart Valve Development
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Heart Valve Formation
Endocardial Cushion Morphogenesis
Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
Chondrocyte Hypertrophy
Growth Plate Cartilage Chondrocyte Growth
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cytoskeleton Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Notch Signaling Pathway
Spermatogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Neural Crest Cell Development
Neural Crest Cell Fate Specification
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Male Germ-line Sex Determination
CAMP-mediated Signaling
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Negative Regulation Of Ossification
Negative Regulation Of Bone Mineralization
Prostate Gland Development
Negative Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Notochord Development
Otic Vesicle Formation
Endocrine Pancreas Development
Negative Regulation Of Chondrocyte Differentiation
Positive Regulation Of Chondrocyte Differentiation
Lacrimal Gland Development
Protein Localization To Nucleus
Somatic Stem Cell Population Maintenance
Intrahepatic Bile Duct Development
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Fatty Acid Oxidation
Negative Regulation Of Photoreceptor Cell Differentiation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Cartilage Development
Sertoli Cell Differentiation
Sertoli Cell Development
Astrocyte Fate Commitment
Retina Development In Camera-type Eye
Limb Bud Formation
Retinal Rod Cell Differentiation
Epithelial Tube Branching Involved In Lung Morphogenesis
Lung Epithelial Cell Differentiation
Epithelial Cell Proliferation Involved In Prostatic Bud Elongation
Bronchus Cartilage Development
Trachea Cartilage Development
Intestinal Epithelial Structure Maintenance
Regulation Of Cell Proliferation Involved In Tissue Homeostasis
Positive Regulation Of Cartilage Development
Regulation Of Branching Involved In Lung Morphogenesis
Morphogenesis Of A Branching Epithelium
Lung Smooth Muscle Development
Protein-containing Complex Assembly
Negative Regulation Of Biomineral Tissue Development
ERK1 And ERK2 Cascade
Harderian Gland Development
Response To Fatty Acid
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Interleukin-1
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Heparin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Renal Vesicle Induction
Ureter Urothelium Development
Ureter Smooth Muscle Cell Differentiation
Ureter Morphogenesis
Metanephric Nephron Tubule Formation
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Positive Regulation Of Kidney Development
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Anterior Head Development
Cell-cell Adhesion
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Chondrocyte Proliferation
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Beta-catenin-TCF Complex Assembly
Positive Regulation Of Male Gonad Development
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Positive Regulation Of Mesenchymal Stem Cell Differentiation
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Pathways
Deactivation of the beta-catenin transactivating complex
Transcriptional regulation by RUNX2
Transcriptional regulation of testis differentiation
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Drugs
Adenosine phosphate
Naloxone
Diseases
46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
Campomelic dysplasia (CD)
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Adolescent idiopathic scoliosis (severe) (
24023777
)
Cervical cancer (
31488892
)
Cervical cancer (MTAG) (
31488892
)
Chin dimples (
27182965
)
Chronic obstructive pulmonary disease (
30804561
)
Coronary artery calcification (
23870195
)
Facial morphology (
31763980
)
Femoral neck bone mineral density (
22504420
)
Fractures (paediatric) (
32742401
)
Gynecologic disease (multivariate analysis) (
31488892
)
Hip bone size (
31053729
)
Hyperthyroidism (
30367059
)
Intertrochanteric region size (
31053729
)
Kidney stones (
31729369
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Lung adenocarcinoma (
28604730
)
Lung cancer (
28604730
)
Nose morphology (
29921221
)
Nose size (
27182965
)
Prostate cancer (
24753544
)
Pulmonary function (smoking interaction) (
23284291
)
Pulmonary function decline (
22424883
)
Thyroid hormone levels (
23408906
)
Thyroid stimulating hormone levels (
32769997
)
Thyrotoxic hypokalemic periodic paralysis and Graves disease (
31050781
)
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Interacting Genes
17 interacting genes:
ATP6V1H
CREB1
CREB3L4
CREBBP
ELF3
EP300
FBXW7
HERC1
HSPA1A
KPNB1
MAF
MED12
NR5A1
RUNX2
SPEN
TRAF2
UBE2I
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
Entrez ID
6662
1385
HPRD ID
06427
00442
Ensembl ID
ENSG00000125398
ENSG00000118260
Uniprot IDs
P48436
B7Z5C6
P16220
Q53X93
Q5U0J5
PDB IDs
1S9M
1SX9
4EUW
2LXT
5ZK1
5ZKO
Enriched GO Terms of Interacting Partners
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