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CREB1 and HNF1B
Data Source:
BioGRID
(two hybrid)
CREB1
HNF1B
Description
cAMP responsive element binding protein 1
HNF1 homeobox B
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Axon
ATF4-CREB1 Transcription Factor Complex
Chromatin
Nucleus
Nucleoplasm
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Response To Hypoxia
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Aging
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Organic Substance
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Activity
Viral Process
Pituitary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonic Acid
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Drug
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Fatty Acid
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Neuron Death
Response To L-glutamate
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Kidney Development
Regulation Of Transcription By RNA Polymerase II
Response To Carbohydrate
Response To Organic Cyclic Compound
Insulin Secretion
Pancreas Development
Circadian Regulation Of Gene Expression
Regulation Of Pronephros Size
Pronephric Nephron Tubule Development
Response To Drug
Positive Regulation Of Transcription, DNA-templated
Embryonic Morphogenesis
Pronephros Development
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Protein-DNA Complex Assembly
Hepatocyte Differentiation
Pathways
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
Circadian Clock
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
MECP2 regulates transcription factors
NGF-stimulated transcription
NGF-stimulated transcription
HCMV Early Events
Transcriptional regulation of granulopoiesis
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ADORA2B mediated anti-inflammatory cytokines production
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Regulation of gene expression in early pancreatic precursor cells
Drugs
Adenosine phosphate
Naloxone
Diseases
Maturity onset diabetes of the young (MODY)
Type II diabetes mellitus
Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS
Body mass index (
28892062
25673413
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Benign prostatic hyperplasia and lower urinary tract symptoms (
30410027
)
Blood urea nitrogen levels (
31152163
29403010
)
Body mass index (
28892062
)
Cancer (
27197191
)
Cancer (pleiotropy) (
27197191
)
Endometrial cancer (
30093612
27008869
21499250
27135401
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Epithelial ovarian cancer (
25581431
)
Frontotemporal dementia (
26154020
)
Gallstone disease (
30504769
)
Medication use (drugs used in diabetes) (
31015401
)
Neuritic plaque (
25188341
)
Ovarian cancer (
23535730
)
Pancreatic cancer (
29422604
)
Pancreatic ductal adenocarcinoma (
30541042
)
Prostate cancer (
20676098
18264096
18264097
30410027
31562322
25939597
26443449
27262462
)
Prostate-specific antigen levels (
30410027
28139693
)
Serum prostate-specific antigen levels (
21160077
)
Testicular germ cell tumor (
25877299
28604728
28604732
)
Type 2 diabetes (
22885922
24509480
30054458
30297969
26818947
23945395
22961080
32499647
20581827
30718926
28869590
)
Interacting Genes
80 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
CAMK2A
CCDC6
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
DNMT3L
DYRK1A
EDF1
ERG28
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
KIAA2026
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
17 interacting genes:
ATF1
BPIFA1
C10orf55
CREB1
CREBBP
CRX
H3C1
HNF1A
KRTAP26-1
MLLT10
OTX2
OXER1
PCBD1
POU6F2
UFSP1
USP54
VAC14
Entrez ID
1385
6928
HPRD ID
00442
08926
Ensembl ID
ENSG00000118260
ENSG00000275410
Uniprot IDs
B7Z5C6
P16220
Q53X93
Q5U0J5
A0A087WZC2
A0A0C4DGS8
E0YMJ6
P35680
Q6FHW6
PDB IDs
2LXT
5ZK1
5ZKO
2DA6
2H8R
5K9S
Enriched GO Terms of Interacting Partners
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