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SOX4 and IGF1
Data Source:
BioGRID
(two hybrid)
SOX4
IGF1
Description
SRY-box transcription factor 4
insulin like growth factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Extracellular Region
Extracellular Space
Insulin-like Growth Factor Binding Protein Complex
Platelet Alpha Granule Lumen
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Insulin-like Growth Factor Ternary Complex
Exocytic Vesicle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
MiRNA Binding
Sequence-specific Double-stranded DNA Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Biological Process
Skeletal System Development
Neural Tube Formation
Pro-B Cell Differentiation
Mitral Valve Morphogenesis
Cardiac Ventricle Formation
Cardiac Right Ventricle Morphogenesis
Atrial Septum Primum Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Glial Cell Proliferation
Spinal Cord Development
Spinal Cord Motor Neuron Differentiation
Glial Cell Development
Cell Differentiation
T Cell Differentiation
Endocrine Pancreas Development
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of Insulin Secretion
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Glucose Homeostasis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Protein Stabilization
Limb Bud Formation
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Neuroepithelial Cell Differentiation
Kidney Morphogenesis
Hematopoietic Stem Cell Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of N-terminal Peptidyl-lysine Acetylation
Activation Of MAPK Activity
Skeletal System Development
Cell Activation
Platelet Degranulation
Signal Transduction
Ras Protein Signal Transduction
Muscle Organ Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Heat
Glycolate Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Muscle Hypertrophy
Myotube Cell Development
Positive Regulation Of Smooth Muscle Cell Migration
Proteoglycan Biosynthetic Process
Positive Regulation Of Cell Migration
Activation Of Protein Kinase B Activity
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Bone Mineralization Involved In Bone Maturation
Regulation Of Multicellular Organism Growth
Wound Healing
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Myoblast Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Positive Regulation Of Ras Protein Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Myoblast Proliferation
Negative Regulation Of Oocyte Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Trophectodermal Cell Proliferation
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Deactivation of the beta-catenin transactivating complex
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases
Malignant pleural mesothelioma
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Bone mineral density (
21533022
)
Cardiac hypertrophy (
21348951
)
Endometrial cancer (
30093612
27008869
)
Endometrial cancer (endometrioid histology) (
30093612
)
Metabolite levels (
23823483
)
Pulmonary function (smoking interaction) (
23284291
)
Birth weight (
31043758
27680694
)
Brain morphology (MOSTest) (
32665545
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Fasting blood insulin (
20081858
22581228
)
Fasting blood insulin (BMI interaction) (
22581228
)
FEV1 (
30804560
)
Height (
25429064
19893584
31562340
31217584
20189936
)
Homeostasis model assessment of insulin resistance (
20081858
)
Insulin-related traits (multivariate analysis) (
32002517
)
Intraocular pressure (
29617998
29785010
)
Lung function (FVC) (
30804560
)
Mammographic density (dense area) (
25342443
)
Offspring birth weight (
31043758
)
Peak expiratory flow (
30804560
)
Refractive error (
32231278
)
Response to quetiapine in schizophrenia (
29503163
)
Systolic blood pressure (
30224653
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
34 interacting genes:
AKT1
APOC3
AURKA
CAPN15
CDKN2A
CTR9
DACH1
EDF1
FOXH1
FZR1
IGF1
ITIH1
KRAS
MINPP1
MNT
MYC
NANOGNB
NF1
NF2
NSD3
PLD3
PLXNB1
RGSL1
RHOU
RP1L1
SCNN1G
SDCBP
SMARCA4
STK11
TERT
TNNI3
TSC1
UBE2I
WT1
22 interacting genes:
BANP
CCN3
CCN5
CTSB
E2F1
ENKD1
IDE
IGF1R
IGFALS
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
IGSF1
MESD
MKRN3
SOX4
TCEANC
TF
Entrez ID
6659
3479
HPRD ID
01695
00936
Ensembl ID
ENSG00000124766
ENSG00000017427
Uniprot IDs
Q06945
P05019
Q13429
Q59GC5
Q5U743
PDB IDs
1B9G
1BQT
1GF1
1GZR
1GZY
1GZZ
1H02
1H59
1IMX
1PMX
1TGR
1WQJ
2DSP
2DSQ
2DSR
2GF1
3GF1
3LRI
4XSS
5U8Q
6FF3
6PYH
6RVA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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